Zhijian J Chen Selected Research

Bites and Stings (Sting)

1/2022	Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer.
1/2022	TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance.
11/2021	MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.
1/2021	cGAS restricts colon cancer development by protecting intestinal barrier integrity.
1/2021	TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections.
1/2020	STEEP mediates STING ER exit and activation of signaling.
1/2020	Old dogs, new trick: classic cancer therapies activate cGAS.
1/2020	Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway.
1/2019	cGAS in action: Expanding roles in immunity and inflammation.
1/2019	Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.

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Zhijian J Chen Research Topics

Disease

33	Bites and Stings (Sting) 01/2022 - 10/2008
21	Infections 01/2021 - 10/2005
17	Neoplasms (Cancer) 11/2021 - 03/2004
15	Virus Diseases (Viral Diseases) 09/2017 - 09/2005
9	Inflammation (Inflammations) 01/2021 - 08/2005
5	Autoimmune Diseases (Autoimmune Disease) 10/2015 - 03/2009
4	Persistent Infection 10/2017 - 01/2002
3	Carcinogenesis 01/2020 - 03/2013
3	DNA Virus Infections 09/2013 - 02/2013
2	Communicable Diseases (Infectious Diseases) 01/2021 - 10/2017
2	Pathologic Processes 01/2020 - 01/2011
2	Ischemia 12/2018 - 12/2003
2	Myocardial Infarction 12/2018 - 12/2003
2	Porcine Reproductive and Respiratory Syndrome (PRRS) 09/2018 - 01/2014
2	Tuberculosis (Tuberculoses) 10/2017 - 06/2015
2	Melanoma (Melanoma, Malignant) 01/2017 - 01/2017
2	RNA Virus Infections 02/2014 - 08/2013
2	Herpes Simplex 01/2009 - 12/2007
1	Arthritis (Polyarthritis) 01/2022
1	Triple Negative Breast Neoplasms 01/2022
1	Chromosome Aberrations (Chromosome Abnormalities) 11/2021
1	Genomic Instability 11/2021
1	Human Influenza (Influenza) 12/2018
1	Rupture 12/2018
1	Fatty Liver 01/2018
1	Obesity 01/2018
1	Malaria 10/2017
1	Lung Neoplasms (Lung Cancer) 02/2017
1	Colonic Neoplasms (Colon Cancer) 01/2017
1	Lymphoma (Lymphomas) 04/2014
1	HIV Infections (HIV Infection) 08/2013
1	Breast Neoplasms (Breast Cancer) 03/2013
1	Hepatitis B 11/2012

Drug/Important Bio-Agent (IBA)

32	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2002
22	Interferon Type IIBA 01/2022 - 09/2005
22	cyclic guanosine monophosphate-adenosine monophosphateIBA 01/2021 - 02/2013
21	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 08/2009
20	InterferonsIBA 01/2022 - 01/2002
16	Antiviral Agents (Antivirals)IBA 01/2021 - 01/2002
12	Transcription Factors (Transcription Factor)IBA 01/2021 - 03/2004
10	CytokinesIBA 01/2019 - 10/2009
7	Phosphotransferases (Kinase)IBA 01/2021 - 03/2012
6	UbiquitinIBA 02/2017 - 03/2004
5	Pattern Recognition ReceptorsIBA 12/2018 - 09/2011
5	Toll-Like Receptors (Toll-Like Receptor)IBA 09/2018 - 09/2008
5	NF-kappa B (NF-kB)IBA 01/2009 - 12/2003
4	RNA (Ribonucleic Acid)IBA 09/2018 - 08/2009
4	Nucleic AcidsIBA 09/2018 - 05/2012
3	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA 01/2021 - 03/2012
3	LigandsIBA 01/2019 - 07/2013
3	Pathogen-Associated Molecular Pattern MoleculesIBA 01/2019 - 08/2008
3	Adenosine Monophosphate (AMP)IBA 01/2019 - 11/2017
3	Carrier Proteins (Binding Protein)IBA 02/2013 - 08/2005
2	Membrane Proteins (Integral Membrane Proteins)IBA 01/2019 - 10/2008
2	PrionsIBA 04/2017 - 03/2014
2	Mitochondrial DNA (mtDNA)IBA 01/2017 - 12/2014
2	Caspase 8 (Caspase-8)IBA 02/2014 - 02/2012
2	Mitochondrial Proteins (Mitochondrial Protein)IBA 08/2013 - 08/2011
2	RNA Helicases (RNA Helicase)IBA 05/2013 - 08/2011
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 03/2013 - 02/2012
2	PolyubiquitinIBA 02/2012 - 03/2004
2	Ligases (Synthetase)IBA 02/2012 - 03/2009
2	Peptide Hydrolases (Proteases)FDA Link 02/2012 - 12/2005
2	Poly I-CIBA 08/2008 - 05/2006
1	ChemokinesIBA 01/2022
1	Neutralizing AntibodiesIBA 01/2022
1	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 01/2022
1	Immune Checkpoint InhibitorsIBA 01/2022
1	deoxyribonuclease II (DNASE II)IBA 01/2022
1	exodeoxyribonuclease IIBA 11/2021
1	InterleukinsIBA 01/2021
1	Interferon alpha-beta Receptor (Receptor, Interferon alpha beta)IBA 01/2021
1	EnzymesIBA 01/2021
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2020
1	GTP Phosphohydrolases (GTPases)IBA 01/2019
1	Virulence Factors (Pathogenicity Factors)IBA 12/2018
1	DNA receptor (receptor, DNA)IBA 12/2018
1	A-Form DNA (A-DNA)IBA 01/2018
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2018
1	Guanosine Monophosphate (5' Guanylic Acid)IBA 01/2018
1	Insulin (Novolin)FDA Link 01/2018
1	Sterol Regulatory Element Binding Protein 1IBA 01/2018
1	VaccinesIBA 10/2017
1	torinIBA 09/2017
1	Mechanistic Target of Rapamycin Complex 1IBA 09/2017
1	Mechanistic Target of Rapamycin Complex 2IBA 09/2017
1	AntigensIBA 01/2017
1	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2017
1	NanovaccinesIBA 01/2017
1	Threonine (L-Threonine)FDA Link 03/2015
1	Serine (L-Serine)FDA Link 03/2015
1	Immunoglobulin M (IgM)IBA 12/2014
1	Antigen Receptors (Antigen Receptor)IBA 04/2014
1	Caspase 3 (Caspase-3)IBA 02/2014
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2013
1	TNF Receptor-Associated Factor 2 (TRAF2)IBA 03/2013

Therapy/Procedure

5	Immunotherapy 11/2021 - 01/2017
4	Therapeutics 11/2021 - 02/2012
3	Radiotherapy 01/2020 - 11/2014
1	Drug Therapy (Chemotherapy) 01/2020